Tongkat Ali leaves extract

Apart from our unchanged-since-1998 Tongkat Ali 1:200 root extract, we also produce Tongkat Ali leaves extract, and we are the only company worldwide that does so on a commercial scale.

Compared to roots, leaves have 20-fold eurycomanone. Leaves contain more than 6 mcg eurycomanone per mL, roots just 0.3 mcg per mL
Source: Biotechnology Journal
https://journals.utm.my/
jurnalteknologi/
article
/view/6011.

Because of the high eurycomanone content in leaves, extracts that use leaves tend to spike testosterone synthesis, and on the short run are therefore more agitating than extracts without leaves. This can cause insomnia in some people.

As shown in scientific research, eurycomanone at higher dosages increases free testosterone via the inhibition of aromatase. Aromatase is an enzyme which breaks down circulating testosterone and converts it into estrogens. This is doubly awkward because not only does aromatase reduce bioavailable testosterone; it actually converts testosterone into anti-testosterone. Eurycomanone limits this reaction.

At high enough dosages, eurycomanone also acts as phosphodiesterase inhibitor. Mind you, drugs like sildenafil are phosphodiesterase inhibitors.

https://pubmed.ncbi.nlm.
nih.gov/23810842/

Tongkat Ali, eurycomanone, and 5-alpha reductase

References:

Abdulelah, Furqan M. ; Abdulbaqi, Mustafa R.; Jaafar, Zahraa M. (2021) Ex-Vivo Anticancer Evaluation of Tongkat Ali Roots Extract Against Lymphocyte Cell Line of Human CML Patient, Systematic Reviews in Pharmacy Volume 12(1) Pages 1206-1211

Abouhamraa, Hamza (2013), Effect of Eurycoma longifolia (Tongkat Ali) on the prostate cancer cell line LNCaP, University of the Western Cape, ETD Repository

Alloha, Irani Binti; Aziz, Nurul ‘Ain Liyana Binti; Faisal, Ghasak Ghazi; Abllah, Zurainie; Arzmi, Mohd Hafiz (2019), Effects of Eurycoma Longifolia Jack (Tongkat Ali) Alcoholic Root Extract Against Oral Pathogens, Pharmacognosy Journal, Volume 11,Issue 6,Pages 1299-1302

Ang, H. H.; Ngai, T. H. (2001), Aphrodisiac evaluation in non-copulator male rats after chronic administration of Eurycoma longifolia Jack, Fundamental and Clinical Pharmacology, Volume15, Issue4, Pages 265-268

Ang, H. H,; Sim, M. K. (1997), Effects of Eurycoma longifolia Jack on Penile Erection Index and Homosexual Mounting in Rats, Pharmacy and Pharmacology Communications, Volume 3, Issue 2, Pages 117-119

Bedir, Erdal; Abou-Gazar, Hassan; Ngwendson, Julius Ngunde; Khan, Ikhlas Ahmad (2003), Eurycomaoside: A New Quassinoid-Type Glycoside from the Roots of Eurycoma longifolia, Chemical and Pharmaceutical Bulletin, Volume 51, Issue 11, Pages 1301-1303

Bhat, Rajeev; Karim, A.A. (2010), Tongkat Ali (Eurycoma longifolia Jack): A review on its ethnobotany and pharmacological importance, Fitoterapia, Volume 81, Issue 7, Pages 669-679

Bin Mohd Tambi M.I.; Imran M.K. (2010), Eurycoma longifolia Jack in managing idiopathic male infertility , Asian Journal of Andrology, Volume 12 Pages 376-380, https://doi.org/10.1038/aja.2010.7

Chen Y, Phang WM, Mu AK, Chan CK, Low BS, Sasidharan S, Chan KL. (2015), Decreased expression of alpha-2-HS glycoprotein in the sera of rats treated with Eurycoma longifolia extract Frontiers in Pharmacology, Vol 6 Page 211

Chua, Lee Suan; Lau, Cher Haan; Chew, Chee Yung; Ali, Dawood; Dawood, Salim (2019), Solvent Fractionation and Acetone Precipitation for Crude Saponins from Eurycoma longifolia Extract, Molecules Volume 24 Issue 7 10.3390/molecules24071416

Danial, Monica; Saghal, Geethaa; Mubbarakh, Safiah Ahmad (2013), Antibacterial Studies On In Vivo Plant Parts of Medicinally Important Eurycoma Longifolia (Tongkat Ali), Pakistan Journal of Botany, Volume 45(5), Pages 1693-1700, 2013.

Faisal, Ghasak G; Najmuldeen, Ghazi F; Abllah, Zurainie; Radeef, Ali S (2017), The Cholesterol Lowering Effects of Eurycoma longifolia Jack (Tongkat Ali) Root Extract in Male Rats. Makara Journal of Health Research (MJHR), Vol 21, No 1

George A.; Henkel R. (2014), Phytoandrogenic properties of Eurycoma longifolia as natural alternative to testosterone replacement therapy, Andrologia, Volume 46, Pages 708-721, https://doi.org/10.1111/and.12214

George A, Udani J, Abidin NZ, Yusof A. (2018). Efficacy and safety of Eurycoma longifolia (Physta®) water extract plus multivitamins on quality of life, mood and stress: a randomized placebo-controlled and parallel study. Food Nutrition Resources, Vol 62.

GG, Faisal; SM, Zakaria; GF, Najmuldeen (2015), In Vitro Antibacterial Activity of Eurycoma Longifolia Jack (Tongkat Ali) Root Extract, International Medical Journal of Malaysia, Volume 14, No. 1

Girish, Sonal; Kumar, Suresh; Aminudin, Norhaniza (2015), Tongkat Ali (Eurycoma longifolia): a possible therapeutic candidate against Blastocystis sp., Parasites Vectors, Volume 8, Pages 332

Henkel R.R.; Wang R.; Bassett S.H.; Chen T.; Liu N.; Zhu Y. et al. (2014), Tongkat Ali as a potential herbal supplement for physically active male and female seniors - A pilot study, Pharmacological Research, Volume 28, Pages 544-550, https://doi.org/10.1002/ptr.5017

Hien, Dao Thi Thanh; Long, Tran Phi; Thao, Tran Phuong; Lee, Jeong-Hyung; Trang, Duong Thu; Minh, Nguyen Thi Thu; Cuong, Pham Van; Lan, Dang, Nguyen Hai; Dat, Nguyen Tien (2019), Anti-inflammatory effects of alkaloid enriched extract from roots of Eurycoma longifolia Jack, Asian Pacific Journal of Tropical Biomedicine, Volume : 9 , Issue : 1 , Pages : 18-23

Khanam, Zakia; Shwu Wen, Chew; Bhat, Irshad Ul Haq (2015), Phytochemical screening and antimicrobial activity of root and stem extracts of wild Eurycoma longifolia Jack (Tongkat Ali), Journal of King Saud University - Science, Volume 27, Issue 1, Pages 23-30

Kotirum S.; Ismail S.B.; Chaiyakunapruk N. (2015), Efficacy of Tongkat Ali (Eurycoma longifolia) on erectile function improvement: systematic review and meta-analysis of randomized controlled trials, Complementary Therapies in Medicine Volume 23, Pages 693-698, https://doi.org/10.1016/
j.ctim.2015.07.009u