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Next Nobel Prize for Tongkat Ali leaves extract?



By tongkatali.org
tongkataliorg3@gmail.com
Updated May 6, 2023

In 1969, Chinese scientist Tu Youyou started screening old Chinese scripts for malaria. She found a reference to sweet wormwood, Artemisia annua, in a text written 1600 years earlier. This herbal was then developed into Artemisinin, a drug that saved millions of lives. In 2015, she received the Nobel Prize in Medicine. We missed out in 2015, but mind you: extracts of tongkat ali (Eurycoma longifolia), especially leaves extracts, are an effective anti-malaria treatment, used in Southeast Asia for centuries. Google for: "tongkat ali malaria"

References:

Ang, H. H.; Ngai, T. H. (2001), Aphrodisiac evaluation in non-copulator male rats after chronic administration of Eurycoma longifolia Jack, Fundamental and Clinical Pharmacology, Volume15, Issue4, Pages 265-268

Chaturapanich, G.; Chaiyakul, S.; Verawatnapakul, V.; Yimlamai, T.; Pholpramool, C.(2012), Enhancement of aphrodisiac activity in male rats by ethanol extract of Kaempferia parviflora and exercise training, Andrologia, Vol 44 (Suppl 1), Pages 323-328

Chaipech, S.; Morikawa, T.; Ninomiya, K.; Yoshikawa, M.l; Pongpiriyadacha, Y.; Hayakawa, T.; Muraoka, O. (2012), Structures of two new phenolic glycosides, kaempferiaosides A and B, and hepatoprotective constituents from the rhizomes of Kaempferia parviflora, Chemical and Pharmaceutical Bulletin, Vol 60, Pages 62-69

Chen, Dalin; Li, Hongliang; Li, Wen; Feng, Shuo; Deng, Dingsen (2018), Kaempferia parviflora and Its Methoxyflavones: Chemistry and Biological Activities, Hindawi Journal, Volume 2018 |Article ID 4057456 | https://doi.org/10.1155/2018/4057456

Chivapat, S.; Chavalittumrong, P.; Attawish, A.; Rungsipipat, A. (2010), Chronic toxicity study of Kaempferia parviflora Wall ex. Extract The Thai Journal of Veterinary Medicine, Volume 40 (4), Pages 377-383 https://tci-thaijo.org/index.php/tjvm/article/view/35774/29744

Chivapat, S.; Chavalittumrong, , P.; Attawish, A.; Rungsipipat, A. (2004), Acute and chronic toxicity study of Kaempferia parviflora Wall ex. bak powder, Journal of Thai Traditional and Alternative Medicine, Volume 2 (2), Pages 3-16

Deema P. (2007), Effect of Kaempferia parviflora and Endurance Training on Lactate Threshold in Humans Phitsanulok, Thailand: Naresuan University

Diastuti, Hartiwi; Chasani, Mochammad; Suwandri, Suwandri (2020), Antibacterial Activity of Benzyl Benzoate and Crotepoxide from Kaempferia rotunda L. Rhizome, Indonesian Journal of Chemistry, Vol 20, No 1

GG, Faisal; SM, Zakaria; GF, Najmuldeen (2015), In Vitro Antibacterial Activity of Eurycoma Longifolia Jack (Tongkat Ali) Root Extract, International Medical Journal of Malaysia, Volume 14, No. 1

Girish, Sonal; Kumar, Suresh; Aminudin, Norhaniza (2015), Tongkat Ali (Eurycoma longifolia): a possible therapeutic candidate against Blastocystis sp., Parasites Vectors, Volume 8, Pages 332

Henkel R.R.; Wang R.; Bassett S.H.; Chen T.; Liu N.; Zhu Y. et al. (2014), Tongkat Ali as a potential herbal supplement for physically active male and female seniors - A pilot study , Pharmacological Research, Volume 28, Pages 544-550, https://doi.org/10.1002/ptr.5017

Hien, Dao Thi Thanh; Long, Tran Phi; Thao, Tran Phuong; Lee, Jeong-Hyung; Trang, Duong Thu; Minh, Nguyen Thi Thu; Cuong, Pham Van; Lan, Dang, Nguyen Hai; Dat, Nguyen Tien (2019), Anti-inflammatory effects of alkaloid enriched extract from roots of Eurycoma longifolia Jack, Asian Pacific Journal of Tropical Biomedicine, Volume : 9 , Issue : 1 , Pages : 18-23

Khanam, Zakia; Shwu Wen, Chew; Bhat, Irshad Ul Haq (2015), Phytochemical screening and antimicrobial activity of root and stem extracts of wild Eurycoma longifolia Jack (Tongkat Ali), Journal of King Saud University - Science, Volume 27, Issue 1, Pages 23-30

Kotirum S.; Ismail S.B.; Chaiyakunapruk N. (2015), Efficacy of Tongkat Ali (Eurycoma longifolia) on erectile function improvement: systematic review and meta-analysis of randomized controlled trials, Complementary Therapies in Medicine Volume 23, Pages 693-698, https://doi.org/10.1016/j.ctim.2015.07.009

Moses , Lusia Barek; Bakar ,Mohd Fadzelly Abu; Mamat, Hasmadi, Aziz, Zaleha Abdul (2021), Unfermented Freeze-Dried Leaf Extract of Tongkat Ali (Eurycoma longifolia Jack.) Induced Cytotoxicity and Apoptosis in MDA-MB-231 and MCF-7 Breast Cancer Cell Lines Hindawi, Volume 2021, Article ID 8811236, https://doi.org/10.1155/2021/8811236

Muhamad, Ayu S.; Ooi, Foong K.; Chen, Chee K. (2015), Effects of Eurycoma longifolia on Natural Killer Cells and Endurance Running Performance, International Journal of Sports Science, Volume 5(3) Pages 93-98

Nhan NH, Loc NH. (2017), Production of eurycomanone from cell suspension culture of Eurycoma longifolia , Pharmaceutical Biology Vol 55(1) Pages 2234-2239

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Ruan, Jingya; Li, Zheng; Zhang, Ying; Chen, Yue; Liu, Mengyang; Han, Lifeng; Zhang, Yi; Wang, Tao (2019), Bioactive Constituents from the Roots of Eurycoma longifolia, Molecules, Volume 24(17), Pages 3157; https://doi.org/10.3390/molecules24173157

See, Kwan Li; Tan, Shu Ying; Hirata, Yoshiyuki; Chan, Lai-Keng; Nagaoka, Yasuo; Uesato, Shinichi; Boey, Peng Lim (2021), Biotic elicitation at different feeding time in cell suspension cultures of Eurycoma longifolia Jack, a valuable medicinal plant, for enhancement of cytotoxic activity of bioactive compounds against human colon cancer cell line, In Vitro Cellular & Developmental Biology - Plant, Volume 58, Pages15–27

Sitanggang, Bintang Riris; Prijanti, Ani Retno; Astuty, Hendri (2018), The Role of Pasak Bumi (Eurycoma longifolia Jack) Extract as an Antimalarial Agent Through the Mechanism of Antioxidant Specific Activity (Superoxide Dismutase, SOD and Catalase, CAT) in Plasmodium berghei-Infected Mice, Advanced Science Letters, Volume 24, Number 9


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