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TONGKAT ALI



Tongkatali.org's Indonesian Grade A Tongkat Ali 1:200 Extract, 100 capsules, 300 mg

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 $66 Available on Amazon in (please click): USA (It is easy from any country in the world to order from Amazon USA, and shipping fees are reasonable.)



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Tongkatali.org's Indonesian Tongkat Ali 1:200 Extract, 500 Capsules of 300 mg

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 $570 ($1.14 / Count)



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Tongkatali.org's Indonesian 1:200 Tongkat Ali Extract, 100 grams (3.53 oz)

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 $158 ($39.71 / Ounce)Available on Amazon in (please click): Amazon USA, Canada



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Tongkatali.org's Indonesian Grade A Tongkat Ali 1:200 Extract, 60 Grams (2.17 oz)

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 $120 ($55.30 / Ounce) Available on Amazon in (please click): USA, Canada, Australia (It is easy from any country in the world to order from Amazon USA, and shipping fees are reasonable.)



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Mercury in tongkat ali


NF-kB Inhibitors from Eurycoma longifolia

Abstract

The roots of Eurycoma longifolia have been used in many countries of Southeast Asia to alleviate various diseases including malaria, dysentery, sexual insufficiency, and rheumatism. Although numerous studies have reported the pharmacological properties of E. longifolia, the mode of action of the anti-inflammatory activity has not been elucidated. Bioguided isolation of NF-?B inhibitors using an NF-?B-driven luciferase reporter gene assay led to the identification of a new quassinoid, eurycomalide C (1), together with 27 known compounds including 11 quassinoids (2–12), six alkaloids (13–18), two coumarins (19, 20), a squalene derivative (21), a triterpenoid (22), and six phenolic compounds (23–28) from the extract of E. longifolia. Evaluation of the biological activity revealed that C19-type and C20-type quassinoids, ß-carboline, and canthin-6-one alkaloids are potent NF-?B inhibitors, with IC50 values in the low micromolar range, while C18-type quassinoids, phenolic compounds, coumarins, the squalene derivative, and the triterpenoid turned out to be inactive when tested at a concentration of 30 µM. Eurycomalactone (2), 14,15ß-dihydroklaieanone (7), and 13,21-dehydroeurycomanone (10) were identified as potent NF-?B inhibitors with IC50 values of less than 1 µM.

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Tongkatali.org's Indonesian Grade A Tongkat Ali 1:200 Extract, 45 Grams (1.59 oz)

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 $79 ($49.70 / Ounce) Available on Amazon in (please click): USA, Canada





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Tongkatali.org's Indonesian Grade A Tongkat Ali 1:200 Extract, 40 Grams (1.41 oz)

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 $70 ($49.60 / Ounce) Available on Amazon in (please click): USA, Canada





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Tongkatali.org's Indonesian Tongkat Ali 1:200 Extract, 350 Grams / 0.77 lbs Loose Extract

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 $570 ($46.26 / Ounce)



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7-Methoxy-(9H-ß-Carbolin-1-il)-(E)-1-Propenoic Acid, a ß-Carboline Alkaloid From Eurycoma longifolia, Exhibits Anti-Inflammatory Effects by Activating the Nrf2/Heme Oxygenase-1 Pathway

Abstract

Eurycoma longifolia is an herbal medicinal plant popularly used in Southeast Asian countries. In the present study, we show that 7-methoxy-(9H-ß-carbolin-1-il)-(E)-1-propenoic acid (7-MCPA), a ß-carboline alkaloid isolated from E. longifolia, exerted anti-inflammatory effects by activating the nuclear factor-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. 7-MCPA inhibited lipopolysaccharide (LPS)-induced production of nitric oxide (NO), prostaglandin E2 (PGE2), and interleukin-6 (IL-6) in RAW264.7 cells and rescued C57BL/6 mice from LPS-induced lethality in vivo. LPS-induced expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and IL-6 was also significantly suppressed by treatment of 7-MCPA in RAW264.7 cells. 7-MCPA induced nuclear translocation of Nrf2 and increased transcription of its target genes, such as HO-1.

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Tongkatali.org's Tongkat Ali Extract, 250 grams / 0.55 lbs

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 $67.50 Available on Amazon in (please click): USA, Canada





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Antiinflammatory and analgesic effects of Eurycoma longifolia extracts

Abstract

Eurycoma longifolia is one of the most popular herbal medicines in Southeast Asia. The purpose of this study is to evaluate the analgesic and anti-inflammatory effects of the methanolic extract of E. longifolia roots (TA) in vivo and to investigate the underlying mechanisms. TA was tested for analgesic activity by the hot plate test and acetic acid test in mice. The anti-inflammatory effect of TA was observed in carrageenan-induced paw edema in mice. The in vitro molecular study using macrophage cells was performed to elucidate the relevant mechanism. The analgesic activity of 400 mg/kg TA was higher than that of aspirin in the hot plate test. TA also showed analgesic effects in the acetic acid test in a dose-dependent manner. In carrageenan-induced edema in mice, TA showed an anti-inflammatory effect comparable to that of diclofenac.

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Tongkatali.org's Indonesian Standard 1:50 Tongkat Ali Extract, 50 Grams (1.76 oz)

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 $45($25.60 / Ounce)Available on Amazon in (please click): USA, Canada





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Tongkatali.org's 1:50 Indonesian Grade A Tongkat Ali Extract 100 Capsules 400 mg

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 $90 Available on Amazon in (please click): USA, Australia, Singapore



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A new anti-inflammatory ß-carboline alkaloid from the hairy-root cultures of Eurycoma longifolia

Abstract

One new ß-carboline alkaloid 7-methoxy-(9H-ß-carbolin-1-il)-(E)-1-propenoic acid (1) together with 9-methoxycanthin-6-one (2) and 9-hydroxycanthin-6-one (3) were isolated from the hairy-root cultures of Eurycoma longifolia. The effects of these compounds on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells were investigated.

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Tongkatali.org's Tongkat Ali Shredded Roots, 40 Grams (1.41 oz)

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 $15 Available on Amazon in (please click): USA



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A new anti-inflammatory ß-carboline alkaloid from the hairy-root cultures of Eurycoma longifolia

Abstract

Tongkat Ali (Eurycoma longifolia Jack, family, Simaroubaceae) is traditionally used in Malaysia as health supplement for hypertension, diarrhea, aches, persistent fever, malaria, sexual insufficiency, dysentery, and glandular swelling. In this study, hydroalcoholic extract of Eurycoma longifolia Jack was studied for its antioxidant and in-vitro anti-inflammatory properties. The antioxidant activity (free radical scavenging) was evaluated to determine the total antioxidant capacity of extract Eurycoma longifolia Jack. The DPPH assay showed significant antioxidant activity in all concentrations (10, 25, 50,100 and 250 µg/ml).

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Tongkatali.org's Tongkat Ali 1:100 Extract, 60 Caps @ 300 mg

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 $45 ($0.75 / Count) Available on Amazon in (please click): USA, Canada, Australia (It is easy from any country in the world to order from Amazon USA, and shipping fees are reasonable.)





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Eurycomanone and Eurycomanol from Eurycoma longifolia Jack as Regulators of Signaling Pathways Involved in Proliferation, Cell Death and Inflammation

Abstract

Eurycomanone and eurycomanol are two quassinoids from the roots of Eurycoma longifolia Jack. The aim of this study was to assess the bioactivity of these compounds in Jurkat and K562 human leukemia cell models compared to peripheral blood mononuclear cells from healthy donors. Both eurycomanone and eurycomanol inhibited Jurkat and K562 cell viability and proliferation without affecting healthy cells. Interestingly, eurycomanone inhibited NF-?B signaling through inhibition of I?Ba phosphorylation and upstream mitogen activated protein kinase (MAPK) signaling, but not eurycomanol.

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Tongkatali.org's Tongkat Ali Chipped Roots, 50 Grams

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$18.75 ($10.65 / Ounce)Available on Amazon in (please click): USA, Canada





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Tongkatali.org's Tongkat Ali Extract 1:100 100 Capsules 300 mg

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$60 ($0.60 / Count)Available on Amazon in (please click): USA, Australia, Singapore





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Tongkatali.org's Indonesian Grade A 1:50 Tongkat Ali Extract, 50 Grams (1.76 oz)

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$79 Available on Amazon in (please click): USA, Canada, Australia





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Tongkatali.org's Tongkat Ali Extract, 200 grams / 0.44 lbs

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$54Available on Amazon in (please click): USA





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Tongkatali.org's Indonesian Standard Tongkat Ali 1:200 Extract, 60 Grams (2.17 oz)

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 $45 ($13.82 / Ounce)Available on Amazon in (please click): USA





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Tongkatali.org's Tongkat Ali Extract, 400 Capsules

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 $97.20 ($0.24 / Count)Available on Amazon in (please click): USA





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Tongkatali.org's Tongkat ali Extract, 8 oz (227 Grams)

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 $61.20($7.65 / Ounce)Available on Amazon in (please click): USA





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