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The locations of Sumatra Pasak Bumi (tongkatali.org) in both Indonesia and Thailand are very remote. We are not affected at all by the novel coronavirus. We operate normal.




Tongkatali.org's 350 grams (12.35 oz) Curcuma Longa / Piper Nigrum Extract

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  $112 ($28.36 / Ounce)



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Curcumin, cytokines, and death from the coronavirus disease

First the parameters.

1. Curcumin is a curcuminoid, one of several plant-specific chemicals of Curcuma longa (turmeric).

2. Death from the novel coronavirus occurs mostly from "cytokine storms" when cytokines make the body's immune system runs amok and kill anything in its way, including healthy cells.

So, let's go into details, first on cytokines, then on the plant Curcuma longa.

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Curcumin and the immune system

There are scientific articles absolutely excited about the effects of curcumin on the immune system.

Take the following one for a start. It is included in PubMed, the scientific database of the US public health services:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603973/

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Death from cytokine storm

People suffering from Covid-19 usually do not die from damage inflicted by the virus.

They die from an overreaction of their own immune system. This overreaction is called a cytokine storm.

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Attenuation of myocardial fibrosis with curcumin is mediated by modulating expression of angiotensin II AT1/AT2 receptors and ACE2 in rats

Abstract

Curcumin is known to improve cardiac function by balancing degradation and synthesis of collagens after myocardial infarction. This study tested the hypothesis that inhibition of myocardial fibrosis by curcumin is associated with modulating expression of angiotensin II (Ang II) receptors and angiotensin-converting enzyme 2 (ACE2). Male Sprague Dawley rats were subjected to Ang II infusion (500 ng/kg/min) using osmotic minipumps for 2 and 4 weeks, respectively, and curcumin (150 mg/kg/day) was fed by gastric gavage during Ang II infusion. Compared to the animals with Ang II infusion, curcumin significantly decreased the mean arterial blood pressure during the course of the observation. The protein level of the Ang II type 1 (AT1) receptor was reduced, and the Ang II type 2 (AT2) receptor was up-regulated, evidenced by an increased ratio of the AT2 receptor over the AT1 receptor in the curcumin group (1.2±0.02%) vs in the Ang II group (0.7±0.03%, P<0.05).

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Revealing the Potency of Citrus and Galangal Constituents to Halt SARS-CoV-2 Infection

Abstract

COVID-19 pandemic is a serious problem in the world today. The SARS-CoV-2 virus that causes COVID-19 has important proteins used for its infection and development, namely the protease and spike glycoprotein. The RBD (Receptor Binding Domain) of spike glycoprotein (RBD-S) can bind to the ACE2 (Angiotensin Converting Enzyme-2) receptor at the protease domain (PD) (PD-ACE2) of the host cell, thereby leading to a viral infection. This study aims to reveal the potential of compounds contained in Curcuma sp., Citrus sp., Alpinia galanga, and Caesalpinia sappan as anti SARS-CoV-2 through its binding to 3 protein receptors. The study was conducted by molecular docking using the MOE 2010 program (licensed from Faculty of Pharmacy UGM, Indonesia). The selected protein targets are RBDS (PDB ID:6LXT), PD-ACE2 (PDB ID: 6VW1), and SARS-CoV-2 protease (PDB ID:6LU7).

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Dietary Curcumin Ameliorates Aging-Related Cerebrovascular Dysfunction through the AMPK/Uncoupling Protein 2 Pathway

Abstract

Background/Aims: Age-related cerebrovascular dysfunction contributes to stroke, cerebral amyloid angiopathy, cognitive decline and neurodegenerative diseases. One pathogenic mechanism underlying this effect is increased oxidative stress. Up-regulation of mitochondrial uncoupling protein 2 (UCP2) plays a crucial role in regulating reactive oxygen species (ROS) production. Dietary patterns are widely recognized as contributors to cardiovascular and cerebrovascular disease. In this study, we tested the hypothesis that dietary curcumin, which has an antioxidant effect, can improve aging-related cerebrovascular dysfunction via UCP2 up-regulation. Methods: The 24-month-old male rodents used in this study, including male Sprague Dawley (SD) rats and UCP2 knockout (UCP2-/-) and matched wild type mice, were given dietary curcumin (0.2%). The young control rodents were 6-month-old. Rodent cerebral artery vasorelaxation was detected by wire myograph.

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Review of Anti-Inflammatory Herbal Medicines

Abstract

Medicinal plants and their secondary metabolites are progressively used in the treatment of diseases as a complementary medicine. Inflammation is a pathologic condition that includes a wide range of diseases such as rheumatic and immune-mediated conditions, diabetes, cardiovascular accident, and etcetera. We introduce some herbs which their anti-inflammatory effects have been evaluated in clinical and experimental studies. Curcuma longa, Zingiber officinale, Rosmarinus officinalis, Borago officinalis, evening primrose, and Devil’s claw are some of the introduced medicinal herbs in this review. Since the treatment of inflammation is not a one-dimensional remedy, this review tries to reach a multidimensional therapeutic approach to inflammation with the help of herbal medicine and modification in lifestyle.

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Chronic diseases, inflammation, and spices: how are they linked?

Abstract

Extensive research within the last several decades has revealed that the major risk factors for most chronic diseases are infections, obesity, alcohol, tobacco, radiation, environmental pollutants, and diet. It is now well established that these factors induce chronic diseases through induction of inflammation. However, inflammation could be either acute or chronic. Acute inflammation persists for a short duration and is the host defense against infections and allergens, whereas the chronic inflammation persists for a long time and leads to many chronic diseases including cancer, cardiovascular diseases, neurodegenerative diseases, respiratory diseases, etc. Numerous lines of evidence suggest that the aforementioned risk factors induced cancer through chronic inflammation.

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Review of Anti-Inflammatory Herbal Medicines

Abstract

Medicinal plants and their secondary metabolites are progressively used in the treatment of diseases as a complementary medicine. Inflammation is a pathologic condition that includes a wide range of diseases such as rheumatic and immune-mediated conditions, diabetes, cardiovascular accident, and etcetera. We introduce some herbs which their anti-inflammatory effects have been evaluated in clinical and experimental studies.

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Tongkatali.org's Indonesian Grade A Tongkat Ali 1:200 Extract, 60 Grams (2.17 oz)

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  $120 ($55.30 / Ounce)
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Mercury in tongkat ali


NF-kB Inhibitors from Eurycoma longifolia

Abstract

The roots of Eurycoma longifolia have been used in many countries of Southeast Asia to alleviate various diseases including malaria, dysentery, sexual insufficiency, and rheumatism. Although numerous studies have reported the pharmacological properties of E. longifolia, the mode of action of the anti-inflammatory activity has not been elucidated. Bioguided isolation of NF-?B inhibitors using an NF-?B-driven luciferase reporter gene assay led to the identification of a new quassinoid, eurycomalide C (1), together with 27 known compounds including 11 quassinoids (2–12), six alkaloids (13–18), two coumarins (19, 20), a squalene derivative (21), a triterpenoid (22), and six phenolic compounds (23–28) from the extract of E. longifolia. Evaluation of the biological activity revealed that C19-type and C20-type quassinoids, ß-carboline, and canthin-6-one alkaloids are potent NF-?B inhibitors, with IC50 values in the low micromolar range, while C18-type quassinoids, phenolic compounds, coumarins, the squalene derivative, and the triterpenoid turned out to be inactive when tested at a concentration of 30 µM. Eurycomalactone (2), 14,15ß-dihydroklaieanone (7), and 13,21-dehydroeurycomanone (10) were identified as potent NF-?B inhibitors with IC50 values of less than 1 µM.

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Tongkatali.org's Tongkat Ali Extract, 250 grams / 0.55 lbs

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  $67.50
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Antiinflammatory and analgesic effects of Eurycoma longifolia extracts

Abstract

Eurycoma longifolia is one of the most popular herbal medicines in Southeast Asia. The purpose of this study is to evaluate the analgesic and anti-inflammatory effects of the methanolic extract of E. longifolia roots (TA) in vivo and to investigate the underlying mechanisms. TA was tested for analgesic activity by the hot plate test and acetic acid test in mice. The anti-inflammatory effect of TA was observed in carrageenan-induced paw edema in mice. The in vitro molecular study using macrophage cells was performed to elucidate the relevant mechanism. The analgesic activity of 400 mg/kg TA was higher than that of aspirin in the hot plate test. TA also showed analgesic effects in the acetic acid test in a dose-dependent manner. In carrageenan-induced edema in mice, TA showed an anti-inflammatory effect comparable to that of diclofenac.

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Tongkatali.org's Kaempferia Parviflora Extract 1:60 60 Capsules 500 mg for a Tongkat Ali Stack

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  Out of stock

$22.50

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Tongkatali.org's Indonesian Tongkat Ali 1:200 Extract, 350 Grams / 0.77 lbs Loose Extract

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  $570 ($46.26 / Ounce)



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7-Methoxy-(9H-ß-Carbolin-1-il)-(E)-1-Propenoic Acid, a ß-Carboline Alkaloid From Eurycoma longifolia, Exhibits Anti-Inflammatory Effects by Activating the Nrf2/Heme Oxygenase-1 Pathway

Abstract

Eurycoma longifolia is an herbal medicinal plant popularly used in Southeast Asian countries. In the present study, we show that 7-methoxy-(9H-ß-carbolin-1-il)-(E)-1-propenoic acid (7-MCPA), a ß-carboline alkaloid isolated from E. longifolia, exerted anti-inflammatory effects by activating the nuclear factor-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. 7-MCPA inhibited lipopolysaccharide (LPS)-induced production of nitric oxide (NO), prostaglandin E2 (PGE2), and interleukin-6 (IL-6) in RAW264.7 cells and rescued C57BL/6 mice from LPS-induced lethality in vivo. LPS-induced expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and IL-6 was also significantly suppressed by treatment of 7-MCPA in RAW264.7 cells. 7-MCPA induced nuclear translocation of Nrf2 and increased transcription of its target genes, such as HO-1.

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Tongkatali.org's Butea Superba Extract 1:100 100 Capsules 400 mg

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  $30
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Tongkatali.org's 1:50 Indonesian Grade A Tongkat Ali Extract 100 Capsules 400 mg

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  $90
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A new anti-inflammatory ß-carboline alkaloid from the hairy-root cultures of Eurycoma longifolia

Abstract

One new ß-carboline alkaloid 7-methoxy-(9H-ß-carbolin-1-il)-(E)-1-propenoic acid (1) together with 9-methoxycanthin-6-one (2) and 9-hydroxycanthin-6-one (3) were isolated from the hairy-root cultures of Eurycoma longifolia. The effects of these compounds on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells were investigated.

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Tongkatali.org's Tongkat Ali Shredded Roots, 40 Grams (1.41 oz)

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  $15
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A new anti-inflammatory ß-carboline alkaloid from the hairy-root cultures of Eurycoma longifolia

Abstract

Tongkat Ali (Eurycoma longifolia Jack, family, Simaroubaceae) is traditionally used in Malaysia as health supplement for hypertension, diarrhea, aches, persistent fever, malaria, sexual insufficiency, dysentery, and glandular swelling. In this study, hydroalcoholic extract of Eurycoma longifolia Jack was studied for its antioxidant and in-vitro anti-inflammatory properties. The antioxidant activity (free radical scavenging) was evaluated to determine the total antioxidant capacity of extract Eurycoma longifolia Jack. The DPPH assay showed significant antioxidant activity in all concentrations (10, 25, 50,100 and 250 µg/ml).

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Tongkatali.org's Thai Tongkat Ali-Butea Superba-Mucuna Pruriens-Krachai Dam 60 Grams Loose Extract

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  $22.50
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Tongkatali.org's Kaempferia parviflora (Krachai Dam, Black Ginger) Extract, 70 Grams (2.47 oz)

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  Out of stock

$26.20 ($10.60 / Ounce)

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Tongkatali.org's Tongkat Ali 1:100 Extract, 60 Caps @ 300 mg

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  $22.50 ($0.25 / Count)
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Eurycomanone and Eurycomanol from Eurycoma longifolia Jack as Regulators of Signaling Pathways Involved in Proliferation, Cell Death and Inflammation

Abstract

Eurycomanone and eurycomanol are two quassinoids from the roots of Eurycoma longifolia Jack. The aim of this study was to assess the bioactivity of these compounds in Jurkat and K562 human leukemia cell models compared to peripheral blood mononuclear cells from healthy donors. Both eurycomanone and eurycomanol inhibited Jurkat and K562 cell viability and proliferation without affecting healthy cells. Interestingly, eurycomanone inhibited NF-?B signaling through inhibition of I?Ba phosphorylation and upstream mitogen activated protein kinase (MAPK) signaling, but not eurycomanol.

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Tongkatali.org's 350 Grams / 0.77 lbs Butea Superba Loose Extract

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  $94.50 ($7.67 / Ounce)
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Tongkatali.org's Kaempferia parviflora (Krachai Dam, Black Ginger) Grade A Extract, 70 Grams (2.47 oz)

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  $51 ($20.65 / Ounce)
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Tongkatali.org's 350 Grams / 12.34 oz Rempa Ratus Loose Extract

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  $94.50 ($7.67 / Ounce)



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Tongkatali.org's 350 Grams / 12.34 oz Sirih Leaves Loose Extract

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  $94.50 ($7.67 / Ounce)



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Deli Serdang
North Sumatra 20353
Indonesia
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