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東革阿里葉萃取

除了我們自 1998 年以來一直不變的東革阿里 1:200 根部萃取物之外,我們也生產東革阿里葉部萃取物,而且我們是全球唯一一家以商業規模生產東革阿里葉部萃取物的公司。

相較於根部,葉子中的 eurycomanone 含量是根部的 20 倍。葉子每毫升含有超過 6 微克的金魚子酮,而根每毫升只有 0.3 微克。 資料來源 Biotechnology Journal
https://journals.utm.my/
jurnalteknologi/
article
/view/6011
.

由於葉子中含有大量的 eurycomanone,使用葉子的萃取物往往會刺激睪丸素的合成,因此在短期內會比沒有使用葉子的萃取物更容易令人激動。這可能會導致某些人失眠。

科學研究顯示,劑量較高的 eurycomanone 會透過抑制芳香化酶來增加游離睪酮。芳香化酶是一種可分解循環睾酮並將其轉換成雌激素的酵素。這會造成雙重尷尬,因為芳香化酶不僅會降低生物可用性睾酮,實際上還會將睾酮轉換成抗睾酮。Eurycomanone 可限制這種反應。

劑量夠高時,Eurycomanone 也會扮演磷酸二酯酶抑制劑的角色。請注意,西地那非等藥物也是磷酸二酯酶抑制劑。

https://pubmed.ncbi.nlm.
nih.gov/23810842/

Tongkat Ali, eurycomanone, and 5-alpha reductase

參考資料:

Abdulelah, Furqan M. ; Abdulbaqi, Mustafa R.; Jaafar, Zahraa M. (2021) Ex-Vivo Anticancer Evaluation of Tongkat Ali Roots Extract Against Lymphocyte Cell Line of Human CML Patient, Systematic Reviews in Pharmacy Volume 12(1) Pages 1206-1211

Abouhamraa, Hamza (2013), Effect of Eurycoma longifolia (Tongkat Ali) on the prostate cancer cell line LNCaP, University of the Western Cape, ETD Repository

Alloha, Irani Binti; Aziz, Nurul ‘Ain Liyana Binti; Faisal, Ghasak Ghazi; Abllah, Zurainie; Arzmi, Mohd Hafiz (2019), Effects of Eurycoma Longifolia Jack (Tongkat Ali) Alcoholic Root Extract Against Oral Pathogens, Pharmacognosy Journal, Volume 11,Issue 6,Pages 1299-1302

Ang, H. H.; Ngai, T. H. (2001), Aphrodisiac evaluation in non-copulator male rats after chronic administration of Eurycoma longifolia Jack, Fundamental and Clinical Pharmacology, Volume15, Issue4, Pages 265-268

Ang, H. H,; Sim, M. K. (1997), Effects of Eurycoma longifolia Jack on Penile Erection Index and Homosexual Mounting in Rats, Pharmacy and Pharmacology Communications, Volume 3, Issue 2, Pages 117-119

Bedir, Erdal; Abou-Gazar, Hassan; Ngwendson, Julius Ngunde; Khan, Ikhlas Ahmad (2003), Eurycomaoside: A New Quassinoid-Type Glycoside from the Roots of Eurycoma longifolia, Chemical and Pharmaceutical Bulletin, Volume 51, Issue 11, Pages 1301-1303

Bhat, Rajeev; Karim, A.A. (2010), Tongkat Ali (Eurycoma longifolia Jack): A review on its ethnobotany and pharmacological importance, Fitoterapia, Volume 81, Issue 7, Pages 669-679

Bin Mohd Tambi M.I.; Imran M.K. (2010), Eurycoma longifolia Jack in managing idiopathic male infertility , Asian Journal of Andrology, Volume 12 Pages 376-380, https://doi.org/10.1038/aja.2010.7

Chen Y, Phang WM, Mu AK, Chan CK, Low BS, Sasidharan S, Chan KL. (2015), Decreased expression of alpha-2-HS glycoprotein in the sera of rats treated with Eurycoma longifolia extract Frontiers in Pharmacology, Vol 6 Page 211

Chua, Lee Suan; Lau, Cher Haan; Chew, Chee Yung; Ali, Dawood; Dawood, Salim (2019), Solvent Fractionation and Acetone Precipitation for Crude Saponins from Eurycoma longifolia Extract, Molecules Volume 24 Issue 7 10.3390/molecules24071416

Danial, Monica; Saghal, Geethaa; Mubbarakh, Safiah Ahmad (2013), Antibacterial Studies On In Vivo Plant Parts of Medicinally Important Eurycoma Longifolia (Tongkat Ali), Pakistan Journal of Botany, Volume 45(5), Pages 1693-1700, 2013.

Faisal, Ghasak G; Najmuldeen, Ghazi F; Abllah, Zurainie; Radeef, Ali S (2017), The Cholesterol Lowering Effects of Eurycoma longifolia Jack (Tongkat Ali) Root Extract in Male Rats. Makara Journal of Health Research (MJHR), Vol 21, No 1

George A.; Henkel R. (2014), Phytoandrogenic properties of Eurycoma longifolia as natural alternative to testosterone replacement therapy, Andrologia, Volume 46, Pages 708-721, https://doi.org/10.1111/and.12214

George A, Udani J, Abidin NZ, Yusof A. (2018). Efficacy and safety of Eurycoma longifolia (Physta®) water extract plus multivitamins on quality of life, mood and stress: a randomized placebo-controlled and parallel study. Food Nutrition Resources, Vol 62.

GG, Faisal; SM, Zakaria; GF, Najmuldeen (2015), In Vitro Antibacterial Activity of Eurycoma Longifolia Jack (Tongkat Ali) Root Extract, International Medical Journal of Malaysia, Volume 14, No. 1

Girish, Sonal; Kumar, Suresh; Aminudin, Norhaniza (2015), Tongkat Ali (Eurycoma longifolia): a possible therapeutic candidate against Blastocystis sp., Parasites Vectors, Volume 8, Pages 332

Henkel R.R.; Wang R.; Bassett S.H.; Chen T.; Liu N.; Zhu Y. et al. (2014), Tongkat Ali as a potential herbal supplement for physically active male and female seniors - A pilot study, Pharmacological Research, Volume 28, Pages 544-550, https://doi.org/10.1002/ptr.5017

Hien, Dao Thi Thanh; Long, Tran Phi; Thao, Tran Phuong; Lee, Jeong-Hyung; Trang, Duong Thu; Minh, Nguyen Thi Thu; Cuong, Pham Van; Lan, Dang, Nguyen Hai; Dat, Nguyen Tien (2019), Anti-inflammatory effects of alkaloid enriched extract from roots of Eurycoma longifolia Jack, Asian Pacific Journal of Tropical Biomedicine, Volume : 9 , Issue : 1 , Pages : 18-23

Khanam, Zakia; Shwu Wen, Chew; Bhat, Irshad Ul Haq (2015), Phytochemical screening and antimicrobial activity of root and stem extracts of wild Eurycoma longifolia Jack (Tongkat Ali), Journal of King Saud University - Science, Volume 27, Issue 1, Pages 23-30

Kotirum S.; Ismail S.B.; Chaiyakunapruk N. (2015), Efficacy of Tongkat Ali (Eurycoma longifolia) on erectile function improvement: systematic review and meta-analysis of randomized controlled trials, Complementary Therapies in Medicine Volume 23, Pages 693-698, https://doi.org/10.1016/
j.ctim.2015.07.009u


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