By Sam Sanare

Pfizer’s Blue is a good drug when it comes to engineering erections. Swallow the pill, and if the pill was an enough dosage, then, about an hour later, an erection is assure.

You cannot do this with butea superba (kwao kruea daeng) or tongkat ali. You will have to take them for a while, and then, the effect is not just an erection but an overall improvement to one’s sex life: better libido, and because of increased excitability, better erections, and better orgasms.

If I ingests a sufficiently high dosage of a phosphodiesterase inhibitor (let’s say: 100 mg of Pfizer’s Blue), then I can have sex with a woman I do not really find attractive (probably even with a prostitute). I can have sex with her, because I have an erection (which doesn’t mean that I necessarily would enjoy it). In fact, on a sufficient dosage of a phosphodiesterase inhibitor, I can have an erection without a woman around, and without having sexual thoughts, just by rubbing my member for a minute or two.

Therefore, if the task is some simple plumbing (increased penile inflow, reduced penile outflow), then Pfizer’s Blue is the correct tool. But there’s more to good sex than is provided by a good erection. Foremost, I want to feel desire. I regard appropriate sexual desire as more valuable than easy erections.

In fact, one can have great sex even with a weak erection. But one has to learn this. Most men, particularly when they are not yet in their 50’s or 60’s, sort-of panic when they are with a sex partner, and an erection does not automatically happen (as it used to). But while a proper erection is needed for standard penetrative sex, an erection is not a requirement for a wholesome orgasm. For an orgasm, not even much of an ejaculation is fundamental.

Orgasms are an affair of sexual wiring. Not of sexual plumbing.

Physiologically, they are marked by a impulsive control of the sympathetic nervous system, while during arousal (and the erective state), the parasympathetic nervous system ruled.

Sympathetic nerve impulses, whether in context with an orgasm or determined by other events (alertness, nervousness, fear, panicking, or simply stress), are always anti-arousal and anti-erectile. This is why men who are scared of not generating an automatic erection when with a woman, enter a vicious circle: they are concerned of not achieving a proper erection, which puts the sympathetic nervous system in command, and since the sympathetic nervous system is in command, they will be even less likely to have an erection. Then they panic, and now they could not achieve an erection even when on 200 mg of Pfizer’s Blue.

Yes, if they take the phosphodiesterase inhibitor about an hour before being called to sexual duty, they will surely start out with a sufficient erection, which gives them self-confidence (which supports the parasympathetic nervous system), which will put them in a state where they will be capable of sustaining their erection.

Doesn’t that sound great? Unluckily no.

The reason for this analysis (which will surely sound strange to a great many readers): if you over-emphasize the parasympathetic nervous system, then your sympathetic nervous system will be rather flat. Which means: your orgasmic capability will be decreased.

I started out on the sexual enhancement trail with yohimbine. That is an alpha adrenergic receptor blocker, peculiarly in the pelvic area. Alpha adrenergic receptors are crucial for sympathetic tone in the abdomen (sympathetic tone can be caused either directly by sympathetic nerve impulses, or indirectly by adrenaline, released from the adrenal medullas upon sympathetic stimulation). If you block pelvic alpha adrenergic receptors, you reduce any effect the sympathetic nervous system (directly or via the release of adrenaline) can exert in this part of the body.

I can go without a phosphodiesterase inhibitor when I’m with a girlfriend that has a good sex drive. Without a phosphodiesterase inhibitor (but on a butea superba / tongkat ali alternating regimen), erections may not be as fast as they are on Pfizer’s Blue. But I can enjoy sex (and a great erection!) for a longer time when on butea superba /tongkat ali (in this way, men with a premature ejaculation problem will probably benefit from butea superba and tongkat ali, too), and I have the strongest orgasms of my whole life.

I consider butea superba and tongkat ali superior to phosphodiesterase inhibitors because both are natural substances, and
Pfizer’s Blue is a xenobiotic.

The dissimilarity between natural substances and xenobiotics is that natural substances have been part of the human culture and human evolution for hundreds, thousands, and even millions of years. If we just go back far enough, all life forms on earth are associated to each other.

Testosterone is a masculinizing hormone not just in humans, but in all mammals. And the nervous systems of humans and chickens, and of humans and fish, are structured in essentially the same way (based on ion channels, which open for impulse conduction).

While some substances in the natural world are poisons to some life forms, all life forms are particularly adapted to a huge number of chemical substances that are part of their environment.

Xenobiotics are artificial chemicals that aren’t part of the natural environment of any life form. While xenobiotics may have a positive effect on some conditions or diseases, it can safely be asserted that almost always, they will somehow negatively affect homeostasis. The negative effects may only appear after some time, and they may appear in an unexpected context. But they are real, and with enough research, they can be traced.

A common side effect of xenobiotics is that they are carcinogenous. Or that they interfere with sexual function. Only recently, it has been established that non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (which has been used by millions for many, many years) significantly increase the risk of heart attacks. And dopaminergics such as bromocriptine and cabergoline can, when taken for years, cause pleural thickening, while making pulmonary respiration a painful exercise. Who would want this?

I have to laugh when so-called life extensionists or “experts” of anti-aging medicine recommend a whole assortment of xenobiotic pharmaceutical products. Xenobiotic pharmaceutical products are suggested in the treatment of specific medical conditions for which they can bring relief. They’re not suited for a long-term strategy to enhance overall health. Which is why, most xenobiotic pharmaceuticals justly are prescription drugs. They’re useful only in a somewhat narrow sense, and while I grant that educated non-physicians can make an informative choice on their use, a great many other people should better only use them on the advice of a MD since their unrealistic expectations will certainly not be met by the drug.

The newest style in pharmaceutical advertising (e.g. on the Internet) is that the drug companies aim at the consumer directly by recommending that patients request certain medications from their doctors. The net result of such advertising is that many misled consumers will avoid their physicians to purchase these drugs. Outside of North America and Western Europe, prescription laws are rarely enforced, so US and European citizens on holiday always use stock up when traveling abroad. Besides, even US citizens can purchase whatever medications they want from overseas sources.

Extended use of xenobiotics is the wrong strategy for a long-term improvement of one’s health. Correct strategies are based on the avoidance of influences that impair one’s health, on proper nutrition, and on the use of herbal supplement (which are a form of nutrition, e.g. the consumption of green tea for problems of alertness, or Brazil nuts to guard against a variety of cancers, or butea superba and tongkat ali for sexual function).

Pfizer’s Blue is a artificial, xenobiotic substance. It does not occur in the natural world. And while Pfizer’s Blue surely works in causing erections, it’s not a medication that would be recommended for day-to-day use to improve one’s overall health. That is why the Pfizer’s Blue package insert (which had to be approved by the FDA) clearly states that the drug is not for everyday use.

If the target is a long-term overall improvement of sexual health and sexual ability, then our best options clearly are butea superba and tongkat ali. They have been used in Southeast Asia for thousands of years, and have been part of the human Southeast Asian habitat for millions of years, so in both ways, our ancestors have often been exposed to it, and habituation has occurred. While the effects of butea superba and tongkat ali maybe not as dramatic as the effects of phosphodiesterase inhibitors on a single-use basis, butea superba and tongkat ali are superior to phosphodiesterase inhibitors since they are suited for a long-term strategy to improve sexual health.